Carvedilol (BCS Class II drug) is a nonselective β-adrenergic blocking agent with α1-blocking activity and it is mainly used in the management of hypertension. Carvedilol has been found to form inclusion complexes with β-Cyclodextrins. The present study was undertaken to determine a suitable method for preparing Carvedilol- β-Cyclodextrin inclusion complexes. Carvedilol- β-Cyclodextrin inclusion complexes were prepared at a molar ratio of 1:1, 1:2 and 1:3 by physical mixing, kneading and solvent evaporation methods. In vitro dissolution studies were carried out in 0.1N HCl. All the methods of preparation of complexes were found to be useful in increasing the solubility of Carvedilol except solvent evaporation method where the rise in solubility is not significant. Kneading method at both 1:2 and 1:3 molar ratios was found to be equally effective in improving the solubility of Carvedilol. In vitro dissolution study data indicated that inclusion complexes prepared by kneading method in 1:2 molar ratios were suitable for improving the solubility of Carvedilol.
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